The Emerging Use of Cannabis in cases of Hyperemesis Gravidarum; A Critical Review

Gideon Koren


There is emerging documentation in both medical journals and social media of American and Canadian women inflicted by hyperemesis gravidarum (HG), reporting beneficial effects of cannabis use on their severe symptoms.

In this review, the risks and benefits of this new therapeutic direction are critically considered. While most professional societies warn pregnant women against the use of cannabis due to potential fetal risks, after 40 years and numerous studies, the fetal risks of cannabis have not been clearly substantiated beyond potential intrauterine growth restriction and prematurity. In contrast, there is new evidence of serious fetal neurodevelopmental risks of HG itself.

A risk: benefit analysis suggests that appropriately- powered studies on the efficacy and fetal safety of cannabis for HG are urgently needed.



cannabis, hyperemesis gravidarum, pregnancy, nausea, vomiting of pregnancy

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