A novel mechanism for induction of Tregs to control allergic disease

Reginald Gorczynski, Hoffmann G


In previous studies we reported immune regulation of colitis, transplanted tissue, and breast cancer in mice could be achieved by modifying immune networks using combinations of immune Ig and anti-idiotypic Ig. We have explored features of this regulation as it relates to altered allergic responses to ovalbumin, exploring attenuation of allergic reactivity in animals receiving combinations of either mouse or heterologous (human) Igs. Our data show a long-lasting suppression of allergic reactivity in mice (>14 weeks post cessation of treatment with Igs). This was seen both in mice receiving treatment from the time of allergen administration (suppression of induction of allergy), as well as in mice already sensitized to allergens before treatment began (suppression of pre-existing symptoms). In either case, attenuation of symptoms was abolished by infusion of T deleting antibodies during the time of Ig administration. Further confirming an importance for induction of (CD4+) Tregs in suppression of allergic responses, we showed that after enrichment, these cells derived from pre-immunized mice treated with combinations of Igs suppressed OVA-induced Th2 responses in cells from fresh populations of immunized animals in vitro. We hypothesize that this treatment regimen opens up new avenues of approach to the treatment of chronic allergic disease in man and in other animals.


Immunoregulation; idiotypic networks; allergic responses; IL-4; IgE

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DOI: http://dx.doi.org/10.18103/imr.v5i8.839


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