Differential Regulation of HOXA10 Gene in Ovarian Cancer and Endometriosis by ESR1

Nancy M. Wang, Yu-Fang Lin, Hsin-Hung Wu


HOXA10 is expressed in development of female reproductive tract and participates in the endometrial differentiation and may contribute to development of endometriosis and epithelial ovarian cancer (EOC). In order to understand its role in differential regulation in these two gynaecological diseases, expressions of HOXA10, ESR1, ESR2 and PGR were examined. Gene expressions were determined in tissues collected from 140 endometriosis patients, 79 EOC patients and 19 women without endometriosis by real-time PCR. Our data showed that expression of HOXA10, ESR1 and PGR, in endometriotic tissues, were 20.1, 1.67 and 3.04 folds lower, respectively, and ESR2 was higher by 4.52 folds. In EOC, expression levels of HOXA10, ESR1 and ESR2 were 1.60 to 2.41 folds higher and PGR was 2.80 folds lower in comparing with normal tissues. The higher expression of HOXA10 in EOC and lower in endometriosis were coincidence with ESR1. In addition, HOXA10 also plays a critical role in regulating the differentiation of EOC to endometrioid and mucinous subtypes. Our study was the first to establish the relationship between hormone control and the expression of HOXA10 in development of these two gynaecological diseases. These results may provide a new focus on the regulated information for hormone therapy, and provide HOXA10 as a potential biomarker for diagnosis the two diseases. 

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DOI: http://dx.doi.org/10.18103/imr.v4i1.625


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