Membrane phospholipid signaling for the regulation of cytoskeleton in neurons

Kimino Minagawa, Hiroshi Hasegawa


Phospholipids are the major component of cellular membrane. They play important roles not only as a structural component of the membrane, but also as signaling mediators of the cell. In addition to the classically known functions of phosphatidylinositol, which is metabolized into different molecular structures with diverse patterns of phosphorylation, as signaling mediators, novel functions of phosphatidylcholine, phosphatidylserine, and sphingomyelin have been clarified in the past decade. Also, dynamic regulation of physical shape of the cellular membrane, which is governed by phospholipid–associating proteins, contribute to the modulation of cellular signaling. In this review article, we summarize the recent advances of our understanding in phospholipid signaling regulating cellular cytoskeletons and their roles in neuronal functions. We will discuss potential usefulness of phospholipid signaling for the drug development of neurological and psychiatric disorders.


phospholipids; neuron; cytoskeleton

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