Polymerase-1 and transcript release factor (PTRF)/ CAVIN1 and cancer: where we are and what is next

Jin-Yih Low


Polymerase I and transcript release factor (PTRF, also known as CAVIN1) is a unique molecule that has been ascribed with two very different functions; RNA transcription termination and caveolae formation. The role of CAVIN1 in cancer has recently gained researchers’ attention and to-date, studies have shown that CAVIN1 may play a role in various malignancies. Here, we will summarize the role of CAVIN1 in cancer and discuss the possible future research directions for CAVIN1.


PTRF, CAVIN1, cancer, therapy,

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DOI: http://dx.doi.org/10.18103/imr.v3i7.524


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